LINCam

Resolve photons spatially and temporarily at the same time

The solution for scanning-free time correlated single photon counting with megapixel positional resolution combined with 40 ps temporal accuracy.

Uncovering LINCam

A comprehensive comparison study of wide-field and confocal approaches for single molecule localization microscopy has been published recently. The authors exploit lifetime as a marker to differentiate several chromophores. Surprisingly, LINCam even with a lower quantum efficiency outperforms the confocal method in number of acquired photons per molecule in addition to outstanding signal-to-noise ratio and excellent lifetime accuracy.

Applications

Light-sheet lifetime imaging

November 12, 2021

Large scale FLIM by optical sectioning of rat embryo. When the size matters.

Measurement induced entanglement of stored ions

October 11, 2021

Stored ions are typical examples for single photon sources that show an antibunched emission statistics. However if two stored ions are brought in an entangled state by simply measuring, interesting phenomena occur.

Spinning Disc

October 11, 2021

Confocal superresolution FLIM microscopy with a spinning disk unit

Glycolytic oscillations in eukaryotic cells followed by NADH imaging

October 11, 2021

By using the metabolite NADH as an intrinsic marker for glycolysis, the dynamics of individual cells can be monitored and their interactions studied.

MIET (Metal induced energy transfer)

July 18, 2021

Metal induced energy transfer (MIET) is a nanoscopy technique to measure distances from fluorescent molecules to a metal film. Here we present MIET acquisition using wide-field and TIRF fluorescence lifetime imaging microscopy (FLIM) equipped with LINCam.

Widefield single molecule acquisition

March 26, 2021

Overcoming the challenge of multilabel imaging with lifetime chromophore separation.

FLIM (Fluorescence Lifetime Imaging)

November 8, 2020

Fluorescence Lifetime Imaging (FLIM) is a technique which uses the separation of different fluorescence decay times of fluorohpores to create an image contrast other than intensity in classical imaging.

Users

Leading universities, research institutes and companies trust in our expertise

About Photonscore

In more than 10 years the of work, the LINCam was developed at the imaging core facility of the Leibniz Institute for Neurobiology in Magdeburg. In 2017, the original Developers Dr.-Ing. Werner Zuschratter, Dr.-Ing. Yury Prokazov and Evgeny Turbin founded the spin-off company Photonscore to further develop this novel quantum light sensor and make it commercial available to various labs, institutes and companies.